We have known for a long time that depression occurs more frequently with multiple sclerosis (MS) than with the general population as a common comorbidity (having two medical conditions at the same time). It has also long been known that there is a genetic risk both for depression and for developing MS. A new study suggests that genetic predisposition for depression may play a role in determining the frequency of relapses and worsening disability in patients with MS.
This study included patients from Sweden and Canada. To determine how heritable depression is, the researchers calculated the number of inherited common genetic variants. They found that a high-risk score of depression based on the genetic variants found was associated with a shorter time to MS relapse and rate of worsening of the MS disability score called the EDSS.
The genetic risk scores do not change over a person’s lifetime and therefore may be able to predict future disease course of those diagnosed with MS. Clinically, this offers a tool to clinicians to individualize therapy in choosing the most appropriate therapeutic interventions. These risk scores are not currently available to clinicians, but researchers hope that they will be before 2030. Currently, the presence of depression in an MS patient may serve as a “red flag” of risk for more aggressive disease.
BeCare MS App can help by quantifiably detecting clinical changes earlier and by assessing mental health through standardized scales. Earlier intervention translates to improved patient outcomes. TAKE ACTION NOW!