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GLP-1 inhibitors as a treatment for Alzheimer’s Disease

GLP-1 inhibitors, like Ozempic, are touted as the panacea to cure all ailments. Large sections of the population are using them for diabetic control and weight loss.  Studies have clearly shown a reduction in cardiovascular risks.

Newer studies suggest that they may also be beneficial in neurodegenerative disorders, such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD).

But how is it that a drug developed for diabetes can help protect the brain against such devastating neurologic disorders?

The theories are that GLP-1 receptor Antagonists can:

  1. Have an impact on all the different types of cell types
  2. Undo or reverse the oxidative stress and its associated cytotoxicity (damage to cells). Oxidative stress occurs due to metabolism when free radicals are formed and there aren’t enough antioxidants to neutralize them. It is commonly associated with factors like obesity, smoking, alcohol, and environmental exposures (air pollution and toxic exposures).
  3. Decrease neuroinflammation
  4. Encourage nerve growth (neurotrophic effects)
  5. Reduce the accumulation of amyloid and tau in the brain, which are thought to be the cause of AD

 

Early evidence suggests that GLP-1 antagonists may become an effective treatment for AD and other neurodegenerative disorders.

BeCareLink can help you determine if you have signs of early cognitive dysfunction, even before you become aware of them, and to track improvement when you begin treatment.

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